Alzheimer and Dementia News - Alz Research & Therapy

Recent Alzheimer's Disease Research Highlights
published on May 17th, 2012 at 07:00 PM
As co-editors of Alzheimer's Research and Therapy we would like to highlight several of the major translational research advances that have occurred over the last year, during which a tremendous ...
Factors that influence survival in a probable Alzheimer disease cohort
published on May 16th, 2012 at 07:00 PM
IntroductionThis longitudinal study examined multiple factors that influence survival in a cohort of Alzheimer patients followed over two decades. Methods: Time to death after symptom onset was ...
Long-term benefit from deep brain stimulation of the subthalamic nucleus: Is it for everyone?
published on May 8th, 2012 at 07:00 PM
Although deep brain stimulation (DBS) has revolutionized our approach to therapy for patients with advanced Parkinson's disease, many questions remain. Should DBS be instituted earlier in the course ...
Examining the mechanisms that link beta-amyloid and alpha-synuclein pathologies
published on April 29th, 2012 at 07:00 PM
β-amyloid (Aβ) and α-synuclein (α-syn) are aggregation-prone proteins typically associated with two distinct neurodegenerative disorders: Alzheimer's disease (AD) and Parkinson's disease. Yet ...
Reduction of low-density lipoprotein receptor-related protein (LRP1) in hippocampal neurons does not proportionately reduce, or otherwise alter, amyloid deposition in APPswe/PS1dE9 transgenic mice
published on April 25th, 2012 at 07:00 PM
IntroductionThe low-density lipoprotein receptor-related protein (LRP1) and its family members have been implicated in the pathogenesis of Alzheimer's disease. Multiple susceptibility factors ...
Relationships between the amyloid precursor protein and its various proteolytic fragments with neuronal systems
published on April 12th, 2012 at 07:00 PM
Alzheimer's disease (AD) is a progressive neurodegenerative disease and in its familial form is associated with mutations in the amyloid precursor protein (APP) and the presenilins (PSs). Much data ...
Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease
published on March 29th, 2012 at 07:00 PM
Mutations in both the amyloid precursor protein (APP) and the presenilin (PSEN) genes cause familial Alzheimer's disease (FAD) with autosomal dominant inheritance and early onset of disease. The ...